张兆强 教授简介

发布者:公共卫生发布时间:2019-07-03浏览次数:1459

张兆强,硕士研究生学历,教授,硕士研究生导师,现为毒理学教研室主任。

教学:承担《毒理学基础》、《职业卫生与职业医学》、《食品毒理学》等课程的教学工作。

科研:研究方向:矽肺纤维化发生机制。主持山东省自然科学基金、山东省卫健委、教育厅、济宁市、皇冠各层次课题8项;以第一作者在国内外期刊发表论文30余篇。

代表性课题:

1.山东省自然科学基金:巨噬细胞TLR4对矽肺纤维化枢纽因子TGFβ1调控的信号通路及医学干预研究,2017-2020,主持。

2.山东省自然科学基金:成纤维细胞中miR-207靶向调控TGF-β1/SMAD3对矽肺纤维化的抑制作用及机制研究,2022-2024,主持。

代表性论文:

1.Zhao-qiang Zhang, Chun-zhi Zhang, Bo Shao, et al. Effects of abnormal expression of fusion and fission genes on the morphology and function of lung macrophage mitochondria in SiO2-induced silicosis fibrosis in rats in vivo. Toxicology Letters. 2019,312:181-187.

2.Zhao-qiang Zhang, Bo Shao, Gui-zhi Han, et al. Location and dynamic changes of inflammation, fibrosis, and expression levels of related genes in SiO2-induced pulmonary fibrosis in rats in vivo. Journal of Toxicologic Pathology. 2019, 32(4):253-260. 

3. Zhao-qiang Zhang, Hai-Tao Tian, Hu Liu, et al. The role of macrophage-derived TGF-β1 on SiO2- induced pulmonary fibrosis: A review. Toxicology and Industrial Health. 2021,37(4):240-250.

4.Zhao-qiang Zhang, Xiao Wu, Gui-zhi Han, Bo Shao, Lin L, Shun-li Jiang. Altered M1/M2 polarization of alveolar macrophages is involved in the pathological responses of acute silicosis in rats in vivo. Toxicol Ind Health. 2022,38(12):810-818.

5. Jia-hui Zhao, Shuang Li, Shu-ling Du, Zhao-qiang Zhang(通信作者). The role of mitochondrial dysfunction in macrophages on SiO2 -induced pulmonary fibrosis: A review. J Appl Toxicol. 2023 Jul 19. doi: 10.1002/jat.4517. Epub ahead of print.

6.Shuang Li, Jiahui Zhao, Guizhi Han, Xin Zhang, Ning Li, Zhaoqiang Zhang(通信作者). Silicon dioxide- induced endoplasmic reticulum stress of alveolar macrophages and its role on the formation of silicosis fibrosis: a review article. 2023,Oct 28. https://doi.org/10.1093/toxres/tfad099. Epub ahead of print.


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